Significant Differences Between Mouse and Human Trophinins Are Revealed by Their Expression Patterns and Targeted Disruption of Mouse Trophinin Gene

• Published in: Biology of reproduction Vol. 66; no. 2; pp. 313 - 321
• Main Authors: NADANO, Daita, SUGIHARA, Kazuhiro, PARIA, Bibhash C, SABURI, Sakura, COPELAND, Neal G, GILBERT, Debra J, JENKINS, Nancy A, NAKAYAMA, Jun, FUKUDA, Michiko N
• Format: Journal Article
• Language: English
• Published: Madison, WI Society for the Study of Reproduction 01.02.2002
• Subjects: Amino Acid Sequence; Animals; Biological and medical sciences; Blastocyst - physiology; Blotting, Southern; Blotting, Western; Cell Adhesion Molecules - biosynthesis; Cell Adhesion Molecules - genetics; Cell Adhesion Molecules - physiology; Chromosome Mapping; Cloning, Molecular; Female; Gene Expression Regulation, Developmental; Genome; Genotype; Humans; Immunohistochemistry; Inbreeding; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity; X Chromosome - genetics

Trophinin has been identified as a membrane protein mediating apical cell adhesion between two human cell lines: trophoblastic HT-H cells, and endometrial epithelial SNG-M cells. Expression patterns of trophinin in humans suggested its involvement in embryo implantation and early placental developme...