Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells

• Published in: Cancer research (Chicago, Ill.) Vol. 59; no. 3; pp. 639 - 644
• Main Authors: IZBICKA, E, WHEELHOUSE, R. T, RAYMOND, E, DAVIDSON, K. K, LAWRENCE, R. A, SUN, D, WINDLE, B. E, HURLEY, L. H, VON HOFF, D. D
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.02.1999
• Subjects: Antineoplastic agents; Antineoplastic Agents - pharmacology; Antineoplastic Agents - toxicity; Biological and medical sciences; Breast Neoplasms - drug therapy; Cations; Cell Nucleus - metabolism; Chemotherapy; DNA - drug effects; DNA - metabolism; DNA, Neoplasm - drug effects; DNA, Neoplasm - metabolism; Enzyme Inhibitors - pharmacology; Enzyme Inhibitors - toxicity; Female; Fibroblasts - drug effects; Fibroblasts - metabolism; G-Quadruplexes; HeLa Cells; Humans; Medical sciences; Models, Molecular; Neoplasms - drug therapy; Neoplasms - metabolism; Pharmacology. Drug treatments; Porphyrins - pharmacokinetics; Porphyrins - pharmacology; Porphyrins - toxicity; Telomerase - antagonists & inhibitors; Telomerase - metabolism; Tumor Cells, Cultured; Adenocarcinoma; Antineoplastic agent; Carcinoma; RNA-directed DNA polymerase; Prostate disease; Mitosis; Cytotoxicity; Telomere; Enzymatic activity; Lymphoproliferative syndrome; Cell cycle; Established cell line; G2 Phase; Malignant lymphoma; Mammary gland; Male genital diseases; Tumor cell; Human; Urinary system disease; Enzyme; Transferases; Enzyme inhibitor; Malignant hemopathy; Malignant tumor; In vitro; Biological activity; Mammary gland diseases; Nucleotidyltransferases; Porphyrin; Prostate

A series of cationic porphyrins has been identified as G-quadruplex interactive agents (QIAs) that stabilize telomeric G-quadruplex DNA and thereby inhibit human telomerase; 50% inhibition of telomerase activity was achieved in HeLa cell-free extract at porphyrin concentrations in the range < or...