Clinical and histopathologic features of canine oxygen-induced proliferative retinopathy

• Published in: Investigative ophthalmology & visual science Vol. 39; no. 10; pp. 1918 - 1932
• Main Authors: McLeod, DS, D'Anna, SA, Lutty, GA
• Format: Journal Article
• Language: English
• Published: Rockville, MD ARVO 01.09.1998; Association for Research in Vision and Ophtalmology
• Subjects: Animals; Animals, Newborn; Apyrase - metabolism; Astrocytes - metabolism; Astrocytes - pathology; Biological and medical sciences; Disease Models, Animal; Dogs; Fluorescein Angiography; Fundus Oculi; Glial Fibrillary Acidic Protein - metabolism; Glycerolphosphate Dehydrogenase - metabolism; Humans; Hyperoxia - complications; Immunoenzyme Techniques; Infant, Newborn; Medical sciences; Ophthalmology; Oxygen - adverse effects; Retina - metabolism; Retina - pathology; Retinal Neovascularization - etiology; Retinal Neovascularization - metabolism; Retinal Neovascularization - pathology; Retinopathies; Retinopathy of Prematurity - etiology; Retinopathy of Prematurity - metabolism; Retinopathy of Prematurity - pathology; Vitreous Hemorrhage - etiology; Vitreous Hemorrhage - metabolism; Vitreous Hemorrhage - pathology; von Willebrand Factor - metabolism; Premature; Fissipedia; Carnivora; Oxygen; Retinopathy; Pathophysiology; Experimental study; Eye disease; Vertebrata; Mammalia; Histopathology; Newborn animal; Dog

In previous studies the morphologic features of the acute vaso-obliterative and vasoproliferative stages of oxygen-induced retinopathy (OIR) were quantified and described in the dog model of retinopathy of prematurity (ROP). In the present study the sequelae of these events were examined using fluor...