Dexamethasone induction of taxol metabolism in the rat

• Published in: Drug metabolism and disposition Vol. 23; no. 11; p. 1286
• Main Authors: Anderson, C D, Wang, J, Kumar, G N, McMillan, J M, Walle, U K, Walle, T
• Format: Journal Article
• Language: English
• Published: United States 01.11.1995
• Subjects: Animals; Antineoplastic Agents, Phytogenic - metabolism; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System - metabolism; Dexamethasone - pharmacology; Female; Glucocorticoids - pharmacology; Humans; Immunoblotting; In Vitro Techniques; Liver - cytology; Liver - drug effects; Liver - metabolism; Male; Microsomes, Liver - drug effects; Microsomes, Liver - enzymology; Microsomes, Liver - metabolism; Paclitaxel - metabolism; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Fast Atom Bombardment

This study examined the effect of dexamethasone (DEX), 100 mg/kg/day for 3 days, on [3H]taxol metabolism in liver microsomes and hepatocytes of male and female Sprague-Dawley rats. In control rats, two isomeric monohydroxylated metabolites, M1 and M2, were formed. The formation of both metabolites w...