Dynamics of Testicular Germ Cell Proliferation in Normal Mice and Transgenic Mice Overexpressing Rat Androgen-Binding Protein: A Flow Cytometric Evaluation

• Published in: Biology of reproduction Vol. 66; no. 4; pp. 877 - 885
• Main Authors: JEYARAJ, D. A, GROSSMAN, G, WEAVER, C, PETRUSZ, P
• Format: Journal Article
• Language: English
• Published: Madison, WI Society for the Study of Reproduction 01.04.2002
• Subjects: Aging; Androgen-Binding Protein - analysis; Androgen-Binding Protein - genetics; Androgens - physiology; Animals; Biological and medical sciences; Cell Division; DNA - biosynthesis; Flow Cytometry; Gene Expression; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Organ Size; Rats; S Phase; Seminiferous Tubules - chemistry; Sperm Count; Spermatids - cytology; Spermatogenesis; Spermatogonia - cytology; Spermatogonia - metabolism; Spermatozoa - chemistry; Spermatozoa - cytology; Testis - chemistry; Testis - cytology; Testis - metabolism

Transgenic mice carrying rat androgen-binding protein (ABP) genomic DNA express high amounts of testicular ABP and develop a progressive impairment of spermatogenesis. To understand the mechanism of these changes, we have studied the pattern of testicular germ cell proliferation from 7 to 360 days o...