Effects of McN-6186 on voltage-dependent Ca++ channels in heart and pituitary cells

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 248; no. 1; pp. 164 - 170
• Main Authors: RAMPE, D, SKATTEBØL, A, TRIGGLE, D. J, BROWN, A. M
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Pharmacology and Experimental Therapeutics 01.01.1989
• Subjects: Amphetamines - pharmacology; Animals; Barium - metabolism; Biological and medical sciences; Calcium - metabolism; Calcium Channel Blockers - pharmacology; Calcium Channels - drug effects; Cardiovascular system; DOM 2,5-Dimethoxy-4-Methylamphetamine - analogs & derivatives; DOM 2,5-Dimethoxy-4-Methylamphetamine - pharmacology; Heart - drug effects; Isradipine; Medical sciences; Membrane Potentials - drug effects; Miscellaneous; Oxadiazoles - metabolism; Pharmacology. Drug treatments; Pituitary Gland - drug effects; Rats; Tumor Cells, Cultured; Heart; Cell culture; Brain; Calcium; Newborn animal; Calcium antagonist; Electrophysiology; Ionic current; In vitro; Biological activity; Tumor cell; Myocyte

McN-6186 (N-[2-(3,5-dimethoxyphenyl)ethyl]-5-methoxy-alpha-methyl-2 -(phenylethynyl) benzeneethanamine hydrochloride is a compound structurally distinct from other Ca++ channel ligands. McN-6186 showed some stimulation of 1,4-dihydropyridine-sensitive Ca++ uptake in neonatal rat ventricular cells at...