Effects of dexamethasone on lymphocyte proliferation and cytokine production in rheumatoid arthritis

• Published in: Journal of rheumatology Vol. 29; no. 1; p. 46
• Main Authors: De, AntonioSergioR, Blotta, Heloisa M, Mamoni, Roney L, Louzada, Paulo, Bertolo, Manoel B, Foss, Norma T, Moreira, Ayrton C, Castro, Margaret
• Format: Journal Article
• Language: English
• Published: Canada 01.01.2002
• Subjects: Adult; Aged; Anti-Inflammatory Agents - pharmacology; Arthritis, Rheumatoid - drug therapy; Arthritis, Rheumatoid - genetics; Arthritis, Rheumatoid - immunology; Biological Assay; Cell Division - drug effects; Cell Division - immunology; Cells, Cultured; Concanavalin A - pharmacology; Cytokines - biosynthesis; Cytokines - immunology; Dexamethasone - pharmacology; Dose-Response Relationship, Drug; Drug Resistance - genetics; Drug Resistance - immunology; Female; Humans; Interferon-gamma - biosynthesis; Interferon-gamma - immunology; Interleukin-10 - biosynthesis; Interleukin-10 - immunology; Interleukin-6 - biosynthesis; Interleukin-6 - immunology; Lymphocytes - drug effects; Lymphocytes - immunology; Lymphocytes - metabolism; Male; Middle Aged; Tumor Necrosis Factor-alpha - biosynthesis; Tumor Necrosis Factor-alpha - immunology

We evaluated the pattern of dexamethasone mediated inhibition of concanavalin-A (Con-A) stimulated peripheral blood mononuclear cell (PBMC) proliferation to classify patients with rheumatoid arthritis (RA) as corticosteroid resistant (CR) or sensitive (CS). We also studied the role of T helper 1, (T...