Effects of Respiratory Rate, Plateau Pressure, and Positive End-Expiratory Pressure on PaO2 Oscillations after Saline Lavage

• Published in: American journal of respiratory and critical care medicine Vol. 166; no. 12; pp. 1556 - 1562
• Main Authors: Baumgardner, James E, Markstaller, Klaus, Pfeiffer, Birgit, Doebrich, Marcus, Otto, Cynthia M
• Format: Journal Article
• Language: English
• Published: New York, NY Am Thoracic Soc 15.12.2002; American Lung Association
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Biological and medical sciences; Bronchoalveolar Lavage; Disease Models, Animal; Emergency and intensive respiratory care; Hemodynamics - drug effects; Intensive care medicine; Logistic Models; Medical sciences; Positive-Pressure Respiration; Pulmonary Atelectasis - etiology; Rabbits; Respiration - drug effects; Respiration, Artificial - adverse effects; Respiratory Distress Syndrome, Adult - etiology; Sodium Chloride - pharmacology; Human; Lung disease; Assisted ventilation; Lung function; Treatment; Atelectasis; Adult respiratory distress syndrome; Respiratory disease; Respiratory intensive care; Exploration

One of the proposed mechanisms of ventilator-associated lung injury is cyclic recruitment of atelectasis. Collapse of dependent lung regions with every breath should lead to large oscillations in PaO2 as shunt varies throughout the respiratory cycle. We placed a fluorescence-quenching PO2 probe in t...