Correlation of in vitro and in vivo growth suppression of MCF-7 human breast cancer by 2,3,7,8-tetrachlorodibenzo-p-dioxin

• Published in: Cancer research (Chicago, Ill.) Vol. 53; no. 13; p. 3149
• Main Authors: Gierthy, J F, Bennett, J A, Bradley, L M, Cutler, D S
• Format: Journal Article
• Language: English
• Published: United States 01.07.1993
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - pathology; Administration, Oral; Animals; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Cell Division - drug effects; Disease Models, Animal; Environmental Exposure; Estradiol - pharmacology; Estrogen Antagonists - pharmacology; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms, Hormone-Dependent - drug therapy; Neoplasms, Hormone-Dependent - pathology; Polychlorinated Dibenzodioxins - pharmacology; Stimulation, Chemical; Transplantation, Heterologous

The purpose of this study was to compare the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the in vitro and in vivo 17 beta-estradiol (E2)-dependent growth of MCF-7 human breast cancer cells. In culture, a major component of postconfluent growth of MCF-7 cells is E2 dependent. In vivo, MCF...