Relationship of the queuine content of transfer ribonucleic acids to histopathological grading and survival in human lung cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 52; no. 17; pp. 4696 - 4700
• Main Authors: Huang, B S, Wu, R T, Chien, K Y
• Format: Journal Article
• Language: English
• Published: United States 01.09.1992
• Subjects: Carcinoma - chemistry; Carcinoma - diagnosis; Carcinoma - pathology; Guanine - analogs & derivatives; Guanine - chemistry; Humans; Lung - chemistry; Lung Neoplasms - chemistry; Lung Neoplasms - diagnosis; Lung Neoplasms - pathology; Neoplasm Staging; Prognosis; RNA, Transfer - chemistry; Survival Analysis

To elucidate the significance of tRNA hypomodified with queuine to the grade of malignancies in human solid tumors, the amount of tRNA having guanosine in place of queuosine was determined in human lung cancer and normal lung tissue, by exchanging the unmodified guanosine residue for [3H]guanine. Th...