Cigarette Smoking, N-Acetyltransferase 2 Acetylation Status, and Bladder Cancer Risk: A Case-Series Meta-analysis of a Gene-Environment Interaction

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 9; no. 5; p. 461
• Main Authors: Marcus, P M, Hayes, R B, Vineis, P, Garcia-Closas, M, Caporaso, N E, Autrup, H, Branch, R A, Brockmöller, J, Ishizaki, T, Karakaya, A E, Ladero, J M, Mommsen, S, Okkels, H, Romkes, M, Roots, I, Rothman, N
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research 01.05.2000
• Subjects: Acetylation; Aged; Aged, 80 and over; Arylamine N-Acetyltransferase - genetics; Arylamine N-Acetyltransferase - metabolism; Case-Control Studies; Female; Genotype; Humans; Male; Middle Aged; Phenotype; Risk Factors; Smoking - adverse effects; Urinary Bladder Neoplasms - enzymology; Urinary Bladder Neoplasms - epidemiology; Urinary Bladder Neoplasms - genetics

Tobacco use is an established cause of bladder cancer. The ability to detoxify aromatic amines, which are present in tobacco and are potent bladder carcinogens, is compromised in persons with the N -acetyltransferase 2 slow acetylation polymorphism. The relationship of cigarette smoking with bladder...