Adriamycin-induced delayed erythropoietic injury expressed following anemia stress

• Published in: Cancer research (Chicago, Ill.) Vol. 40; no. 7; pp. 2257 - 2262
• Main Authors: Braunschweiger, P G, Schenken, L L, Schiffer, L M
• Format: Journal Article
• Language: English
• Published: United States 01.07.1980
• Subjects: Anemia - complications; Anemia - pathology; Anemia - physiopathology; Animals; Body Weight; Bone Marrow - drug effects; Cytarabine - pharmacology; Doxorubicin - pharmacology; Erythropoiesis - drug effects; Female; Femur - drug effects; Iron - metabolism; Mice; Organ Size; Spleen - drug effects; Spleen - pathology

The present studies were undertaken to compare anemia-induced erythropoietic responses in femoral marrows and spleens of mice pretreated with Adriamycin (ADR) or 1-beta-D-arabinofuranosylcytosine with those of untreated age-matched controls. Mice were bled 45 or 120 days after drug treatment. The er...