Potential utility of CD5 immunohistochemical staining in the diagnosis of muscle tumors

• Published in: Annals of clinical and laboratory science Vol. 39; no. 2; pp. 108 - 113
• Main Authors: McNab, Patricia Moody, DeMers, Nicole M, Schlauder, Scott, Morgan, Michael, Nasir, Aejaz, Coppola, Domenico, Bui, Marilyn M
• Format: Journal Article
• Language: English
• Published: United States 2009
• Subjects: Antigens, CD - analysis; CD5 Antigens - analysis; Humans; Immunohistochemistry; Leiomyoma - pathology; Leiomyosarcoma - pathology; Muscle Neoplasms - diagnosis; Muscle Neoplasms - pathology; Muscle, Skeletal - cytology; Muscle, Skeletal - pathology; Muscle, Smooth - cytology; Muscle, Smooth - pathology; Retrospective Studies; Rhabdomyoma - pathology; Rhabdomyosarcoma - pathology; Sarcoma - diagnosis; Sarcoma - pathology; T-Lymphocytes - pathology

CD5 is a 67 KD glycoprotein receptor that is present on a variety of T lymphocytes and mantle zone lymphocytes and is used routinely for the diagnosis of lymphomas and thymic carcinomas. That CD5 may be useful in diagnosis of mesenchymal tumors was an incidental finding in our sarcoma practice. This...