Angiogenic Squamous Dysplasia in Bronchi of Individuals at High Risk for Lung Cancer

• Published in: Clinical cancer research Vol. 6; no. 5; p. 1616
• Main Authors: Keith, R L, Miller, Y E, Gemmill, R M, Drabkin, H A, Dempsey, E C, Kennedy, T C, Prindiville, S, Franklin, W A
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research 01.05.2000
• Subjects: Aged; Bronchi - blood supply; Bronchi - chemistry; Bronchi - pathology; Bronchoscopy; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Cell Division; Chromosomes, Human, Pair 3 - genetics; Endothelium, Vascular - cytology; Endothelium, Vascular - metabolism; Female; Humans; Immunohistochemistry; Ki-67 Antigen - analysis; Loss of Heterozygosity; Lung Neoplasms - pathology; Male; Middle Aged; Mutation; Neovascularization, Pathologic; Platelet Endothelial Cell Adhesion Molecule-1 - analysis; Risk Factors; Tumor Suppressor Protein p53 - genetics

Lung carcinogenesis is assumed to be a multistep process, but detailed understanding of the sequential morphological and molecular changes preceding invasive lung cancer remains elusive. To better understand early lung carcinogenesis, we initiated a program of fluorescence bronchoscopy in smokers at...