Oxygen-induced retinopathy in the rat: relationship of retinal nonperfusion to subsequent neovascularization

• Published in: Investigative ophthalmology & visual science Vol. 35; no. 9; p. 3429
• Main Authors: Penn, JS, Tolman, BL, Henry, MM
• Format: Journal Article
• Language: English
• Published: United States ARVO 01.08.1994
• Subjects: Animals; Animals, Newborn; Disease Models, Animal; Humans; Infant, Newborn; Oxygen - toxicity; Rats; Rats, Sprague-Dawley; Retinal Neovascularization - etiology; Retinal Neovascularization - pathology; Retinal Vessels - drug effects; Retinal Vessels - pathology; Retinopathy of Prematurity - pathology

To confirm a relationship between oxygen-induced retinal vasoattenuation and subsequent abnormal neovascularization in the newborn rat. Beginning at birth, some litters of Sprague-Dawley rats were exposed to 80% constant oxygen while others received oxygen varying between 40% and 80% in a cyclic fas...