Allotype Suppression at the CHn Locus of IgM in Heterozygous Rabbits with Concomitant Suppression at the VHa Locus of All Ig Classes

• Published in: The Journal of immunology (1950) Vol. 119; no. 4; pp. 1369 - 1373
• Main Authors: Gilman-Sachs, Alice, Eskinazi, Daniel P, Dray, Sheldon
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 01.10.1977
• Subjects: Animals; Animals, Newborn; Chromosome Mapping; Female; Heterozygote; Immunoglobulin Allotypes; Immunoglobulin M; Immunoglobulins; Immunosuppression; Isoantigens; Male; Rabbits

Doubly heterozygous offspring, malen83alpha1/femalen82alpha2 or malen81alpha1/femalen82alpha2, of doubly homozygous dams, n82alpha2/n82alpha2, were injected neonatally with anti-n83 or anti-n81 antibody directed to the paternal n locus allotype. In each injected rabbit, the paternal n83 or n81 allot...