The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 270; no. 1; p. 219
• Main Authors: Smith, P B, Compton, D R, Welch, S P, Razdan, R K, Mechoulam, R, Martin, B R
• Format: Journal Article
• Language: English
• Published: United States American Society for Pharmacology and Experimental Therapeutics 01.07.1994
• Subjects: Analgesics - metabolism; Animals; Arachidonic Acids - metabolism; Arachidonic Acids - pharmacokinetics; Arachidonic Acids - pharmacology; Binding, Competitive; Brain - metabolism; Calcium Channel Blockers - metabolism; Calcium Channel Blockers - pharmacokinetics; Calcium Channel Blockers - pharmacology; Cyclohexanols - metabolism; Dronabinol - metabolism; Dronabinol - pharmacokinetics; Dronabinol - pharmacology; Drug Administration Routes; Drug Interactions; Endocannabinoids; Male; Membranes - metabolism; Mice; Mice, Inbred ICR; Naltrexone - analogs & derivatives; Naltrexone - pharmacology; Polyunsaturated Alkamides; Receptors, Purinergic P2 - metabolism; Tritium

The arachidonic acid derivative anandamide (arachidonylethanolamide) has been isolated from porcine brain and has been shown to bind competitively to the cannabinoid receptor. Although the pharmacological activity of this compound has not yet been fully determined, preliminary data suggest that it p...