Homologous dura mater cardiac valves. Study of 533 surgical cases

• Published in: The Journal of thoracic and cardiovascular surgery Vol. 69; no. 5; pp. 722 - 728
• Main Authors: Puig, LB, Verginelli, G, Iryia, K, Kawabe,, L, Bellotti, G, Sosa, E, Pilleggi, F, Zerbini, EJ
• Format: Journal Article
• Language: English
• Published: United States AATS/WTSA 01.05.1975
• Subjects: Adolescent; Adult; Aged; Aortic Valve - surgery; Child; Child, Preschool; Dura Mater - transplantation; Evaluation Studies as Topic; Female; Follow-Up Studies; Heart Murmurs; Heart Valve Prosthesis - methods; Humans; Male; Middle Aged; Mitral Valve - surgery; Polyethylene Terephthalates; Postoperative Complications; Pulmonary Valve - surgery; Stainless Steel; Transplantation, Homologous; Tricuspid Valve - surgery
• ISSN: 0022-5223; 1097-685X
• DOI: 10.1016/s0022-5223(19)41506-7

A group of 533 patients had cardiac valves replaced with homologous dura mater valves. The dura mater was preserved in a solution of 98 per cent glycerol and antibiotics for a period of 12 days before used. The leaflets were mounted in a stainless steel ring covered by Dacron velour. Two hundred forty-five patients had mitral valve replacement; 205 patients, aortic valve replacement; 17 patients, tricuspid valve replacement; and 2 patients, pulmonary valve replacement. Sixty-four patients were subjected to multivalvular replacements. The patients were followed for a period of 1 to 40 months after surgery with satisfactory clinical and hemodynamic results. Because 2 patients developed endocarditis produced by fungii, fungicidal drugs were added to the preservative solution. No bacterial endocarditis has been observed. No pressure gradient through the valve has been noted at rest. Anticoagulant drugs have not been used in the postoperative period.