THE PHYSIOLOGIC DISPOSITION OF H3-HISTAMINE IN THE RAT BRAIN
The physiologic disposition of H 3 -histamine in rat brain has been studied after its intraventricular administration. H 3 -histamine is taken up and retained in the brain. H 3 -histamine disappears from the brain in a multiphasic fashion with a half-life of 1.6 hr during the first 6 hr and a half-l...
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| Published in | The Journal of pharmacology and experimental therapeutics Vol. 153; no. 1; pp. 8 - 14 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Society for Pharmacology and Experimental Therapeutics
01.07.1966
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The physiologic disposition of H 3 -histamine in rat brain has been studied after its intraventricular administration. H 3 -histamine is taken up and retained in the brain. H 3 -histamine disappears from the brain in a multiphasic fashion with a half-life of 1.6 hr during the first 6 hr and a half-life
of 11 hr from 6 to 24 hr. The major metabolic product of H 3 -histamine in brain is H 3 imidazoleacetic acid; a minor product is H 3 -methylhistamine. Subcellular distribution studies using a continuous sucrose gradient showed that the H 3 -histamine is highly localized in the pinched-off nerve ending and microsomal fractions. Monoamine oxidase inhibition elevates
H 3 -histamine levels in rat brain. Reserpine and aminoguanidine have no effect. |
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| AbstractList | The physiologic disposition of H 3 -histamine in rat brain has been studied after its intraventricular administration. H 3 -histamine is taken up and retained in the brain. H 3 -histamine disappears from the brain in a multiphasic fashion with a half-life of 1.6 hr during the first 6 hr and a half-life
of 11 hr from 6 to 24 hr. The major metabolic product of H 3 -histamine in brain is H 3 imidazoleacetic acid; a minor product is H 3 -methylhistamine. Subcellular distribution studies using a continuous sucrose gradient showed that the H 3 -histamine is highly localized in the pinched-off nerve ending and microsomal fractions. Monoamine oxidase inhibition elevates
H 3 -histamine levels in rat brain. Reserpine and aminoguanidine have no effect. |
| Author | Solomon H. Synder Julius Axelrod Jacques Glowinski |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/5921360$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Animals Brain - cytology Brain - metabolism Cell Nucleus - metabolism Chromatography, Paper Histamine - metabolism Imidazoles - metabolism In Vitro Techniques Microsomes - metabolism Mitochondria - metabolism Monoamine Oxidase Inhibitors - pharmacology Rats Tritium - metabolism |
| Title | THE PHYSIOLOGIC DISPOSITION OF H3-HISTAMINE IN THE RAT BRAIN |
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