THE PHYSIOLOGIC DISPOSITION OF H3-HISTAMINE IN THE RAT BRAIN

The physiologic disposition of H 3 -histamine in rat brain has been studied after its intraventricular administration. H 3 -histamine is taken up and retained in the brain. H 3 -histamine disappears from the brain in a multiphasic fashion with a half-life of 1.6 hr during the first 6 hr and a half-l...

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Published inThe Journal of pharmacology and experimental therapeutics Vol. 153; no. 1; pp. 8 - 14
Main Authors Synder, S H, Glowinski, J, Axelrod, J
Format Journal Article
LanguageEnglish
Published United States American Society for Pharmacology and Experimental Therapeutics 01.07.1966
Subjects
Animals
Brain - cytology
Brain - metabolism
Cell Nucleus - metabolism
Chromatography, Paper
Histamine - metabolism
Imidazoles - metabolism
In Vitro Techniques
Microsomes - metabolism
Mitochondria - metabolism
Monoamine Oxidase Inhibitors - pharmacology
Rats
Tritium - metabolism
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Summary:The physiologic disposition of H 3 -histamine in rat brain has been studied after its intraventricular administration. H 3 -histamine is taken up and retained in the brain. H 3 -histamine disappears from the brain in a multiphasic fashion with a half-life of 1.6 hr during the first 6 hr and a half-life of 11 hr from 6 to 24 hr. The major metabolic product of H 3 -histamine in brain is H 3 imidazoleacetic acid; a minor product is H 3 -methylhistamine. Subcellular distribution studies using a continuous sucrose gradient showed that the H 3 -histamine is highly localized in the pinched-off nerve ending and microsomal fractions. Monoamine oxidase inhibition elevates H 3 -histamine levels in rat brain. Reserpine and aminoguanidine have no effect.
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ISSN:0022-3565
1521-0103