Effect of protein tyrosine phosphatase 1B expression on transformation by the human neu oncogene

• Published in: Cancer research (Chicago, Ill.) Vol. 52; no. 2; pp. 478 - 482
• Main Authors: BROWN-SHIMER, S, JOHNSON, K. A, HILL, D. E, BRUSKIN, A. M
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.01.1992
• Subjects: 3T3 Cells - enzymology; Animals; Biological and medical sciences; Cell Division; Cell metabolism, cell oxidation; Cell physiology; Cell Transformation, Neoplastic - metabolism; Fundamental and applied biological sciences. Psychology; genes; Genes, Tumor Suppressor; Humans; Mice; Molecular and cellular biology; neu; NIH 3T3 cells; Oncogenes; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases - metabolism; protein-tyrosine-phosphatase; Proto-Oncogene Proteins - genetics; Receptor, ErbB-2; Transfection; transformation; Phosphorylation; Enzyme; Rodentia; Tumorigenicity; Gene expression; In vitro; Genetic transfer; Vertebrata; Mammalia; Mouse; Animal; Malignant transformation; Inhibition; Onc gene; Protein-tyrosine-phosphatase

Many oncogenes encode proteins with a tyrosine kinase activity that appears to be directly involved in the process of transformation. Because these kinases are themselves activated for transformation by tyrosine phosphorylation, proteins which remove phosphate from tyrosine residues, protein tyrosin...