Thermodynamic limitation for Ca2+ handling contributes to decreased contractile reserve in rat hearts

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 275; no. 6; p. H2064
• Main Authors: Tian, Rong, Halow, Jessica M, Meyer, Markus, Dillmann, Wolfgang H, Figueredo, Vincent M, Ingwall, Joanne S, Camacho, S. Albert
• Format: Journal Article
• Language: English
• Published: United States 01.12.1998
• Subjects: Animals; Calcium - metabolism; Calcium-Transporting ATPases - metabolism; Creatine Kinase - antagonists & inhibitors; Creatine Kinase - metabolism; Cytosol - metabolism; Enzyme Inhibitors - pharmacology; Iodoacetamide - pharmacology; Male; Myocardial Contraction - physiology; Osmolar Concentration; Perfusion; Pressure; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum - drug effects; Sarcoplasmic Reticulum - enzymology; Thermodynamics; Ventricular Function, Left - physiology

1  Nuclear Magnetic Resonance Laboratory for Physiological Chemistry, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; 4  Division of Cardiology, Department of Medicine, San Francisco General Hospital, and 2  Department of Medicine, Univ...