Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects

• Published in: Circulation (New York, N.Y.) Vol. 108; no. 8; pp. 989 - 995
• Main Authors: FONTANA, Pierre, DUPONT, Annabelle, GANDRILLE, Sophie, BACHELOT-LOZA, Christilla, RENY, Jean-Luc, AIACH, Martine, GAUSSEM, Pascale
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 26.08.2003; American Heart Association, Inc
• Subjects: Adenosine Diphosphate - pharmacology; Adolescent; Adult; Alleles; Base Sequence; Biological and medical sciences; Blood and lymphatic vessels; Blood Platelets - drug effects; Blood Platelets - metabolism; Cardiology. Vascular system; Cyclic AMP - metabolism; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Dose-Response Relationship, Drug; Drug Resistance - genetics; Genetic Testing; Genetic Variation; Haplotypes; Heterozygote; Humans; Integrin beta3 - genetics; Male; Medical sciences; Membrane Proteins; Molecular Sequence Data; Platelet Aggregation - drug effects; Platelet Aggregation - genetics; Polymorphism, Genetic; Receptors, Purinergic P2 - genetics; Receptors, Purinergic P2Y12; Reference Values; Human; P2Y12 purinergic receptor; receptors; Cardiovascular disease; ADP; Genetic determinism; Thrombosis; platelets; Vascular disease; Aggregation; Platelet; genetics; Gene; Risk factor

The adenosine diphosphate (ADP) receptor P2Y12 plays a pivotal role in platelet aggregation, as demonstrated by the benefit conferred by its blockade in patients with cardiovascular disease. Some studies have shown interindividual differences in ADP-induced platelet aggregation responses ex vivo, bu...