Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects - FONTANA, Pierre; DUPONT, Annabelle; GANDRILLE, Sophie; BACHELOT-LOZA, Christilla; RENY, Jean-Luc; AIACH, Martine; GAUSSEM, Pascale (Circulation (New York, N.Y.), 2003)
Keywords: Adenosine Diphosphate - pharmacology; Adolescent; Adult; Alleles; Base Sequence; Biological and medical sciences; Blood and lymphatic vessels; Blood Platelets - drug effects; Blood Platelets - metabolism; Cardiology. Vascular system; Cyclic AMP - metabolism; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Dose-Response Relationship, Drug; Drug Resistance - genetics; Genetic Testing; Genetic Variation; Haplotypes; Heterozygote; Humans; Integrin beta3 - genetics; Male; Medical sciences; Membrane Proteins; Molecular Sequence Data; Platelet Aggregation - drug effects; Platelet Aggregation - genetics; Polymorphism, Genetic; Receptors, Purinergic P2 - genetics; Receptors, Purinergic P2Y12; Reference Values; Human; P2Y12 purinergic receptor; receptors; Cardiovascular disease; ADP; Genetic determinism; Thrombosis; platelets; Vascular disease; Aggregation; Platelet; genetics; Gene; Risk factor