SV40 early region and large T antigen in human brain tumors, peripheral blood cells, and sperm fluids from healthy individuals

• Published in: Cancer research (Chicago, Ill.) Vol. 56; no. 20; pp. 4820 - 4825
• Main Authors: MARTINI, F, IACCHERI, L, LAZZARIN, L, CARINCI, P, CORALLINI, A, GEROSA, M, IUZZOLINO, P, BARBANTI-BRODANO, G, TOGNON, M
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.10.1996
• Subjects: Antigens, Viral, Tumor - analysis; Biological and medical sciences; Brain Chemistry; Brain Neoplasms - chemistry; Brain Neoplasms - immunology; DNA, Viral - analysis; Humans; Medical sciences; Neurology; Point Mutation; Polymerase Chain Reaction; Sequence Analysis, DNA; Simian virus 40 - chemistry; Simian virus 40 - immunology; Tumor Cells, Cultured; Tumors of the nervous system. Phacomatoses; Viral Proteins - analysis; Human; Intracranial; Nervous system diseases; Pathogenesis; Polyomavirus; Glioblastoma; Papovaviridae; Malignant tumor; Gene expression; Carcinogenesis; Oligodendroglioma; Virus; Tissue; Blood cell; Central nervous system disease; Histological type; Spongioblastoma; Large T antigen; Seminal plasma; SV40 virus; Astrocytoma; Ependymoma; Meningioma; Immediate early gene

SV40 T antigen (Tag) coding sequences were detected by PCR amplification followed by Southern blot hybridization in human brain tumors and tumor cell lines, as well as in peripheral blood cells and sperm fluids of healthy donors. SV40 early region sequences were found in 83% of choroid plexus papill...