Semenogelin II Gene Is Replaced by a Truncated LINE1 Repeat in the Cotton-Top Tamarin

The human seminal vesicles secrete two proteins, semenogelin I and semenogelin II, at very high concentrations. It has previously been shown that the cotton-top tamarin ( Sanguinus oedipus ), a New World monkey, is lacking the semenogelin II gene. We have now determined the nucleotide sequence of DN...

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Published inBiology of reproduction Vol. 65; no. 2; pp. 420 - 425
Main Authors LUNDWALL, Ake, OLSSON, A. Yvonne M
Format Journal Article
LanguageEnglish
Published Madison, WI Society for the Study of Reproduction 01.08.2001
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Abstract The human seminal vesicles secrete two proteins, semenogelin I and semenogelin II, at very high concentrations. It has previously been shown that the cotton-top tamarin ( Sanguinus oedipus ), a New World monkey, is lacking the semenogelin II gene. We have now determined the nucleotide sequence of DNA located 5–13 kilobases (kb) downstream of the tamarin semenogelin I gene—a region that in man is occupied by the semenogelin II gene. Two regions with homology to the human semenogelin II gene were identified in the tamarin DNA. The first region, of 3.5 kb, is homologous to DNA upstream of the human gene, and the second region, of 0.6 kb, is mainly derived from the second intron. Between these regions, equivalent to 594 base pairs (bp) upstream of the transcription initiation site to 12 bp downstream of the stop codon in the human semenogelin II gene, the cotton-top tamarin DNA carries a truncated LINE1 repeat. In another set of experiments, the tamarin DNA hybridizing to the mouse semenoclotin gene was investigated. It was concluded that hybridization is with the second intron of the semenoclotin gene, but very likely, the material does not represent a cotton-top tamarin semenoclotin gene. Thus, a mammalian ancestor probably carried a single gene that in the rodent lineage developed into the semenoclotin gene and in the primate lineage into a progenitor of the semenogelin genes.
AbstractList The human seminal vesicles secrete two proteins, semenogelin I and semenogelin II, at very high concentrations. It has previously been shown that the cotton-top tamarin ( Sanguinus oedipus ), a New World monkey, is lacking the semenogelin II gene. We have now determined the nucleotide sequence of DNA located 5–13 kilobases (kb) downstream of the tamarin semenogelin I gene—a region that in man is occupied by the semenogelin II gene. Two regions with homology to the human semenogelin II gene were identified in the tamarin DNA. The first region, of 3.5 kb, is homologous to DNA upstream of the human gene, and the second region, of 0.6 kb, is mainly derived from the second intron. Between these regions, equivalent to 594 base pairs (bp) upstream of the transcription initiation site to 12 bp downstream of the stop codon in the human semenogelin II gene, the cotton-top tamarin DNA carries a truncated LINE1 repeat. In another set of experiments, the tamarin DNA hybridizing to the mouse semenoclotin gene was investigated. It was concluded that hybridization is with the second intron of the semenoclotin gene, but very likely, the material does not represent a cotton-top tamarin semenoclotin gene. Thus, a mammalian ancestor probably carried a single gene that in the rodent lineage developed into the semenoclotin gene and in the primate lineage into a progenitor of the semenogelin genes.
Author A. Yvonne M. Olsson
Åke Lundwall
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Issue 2
Keywords Vertebrata
Mammalia
Saguinus oedipus
Semenogelin
Gene
Nucleotide sequence
Seminal vesicle
Primates
Simioidea
Molecular cloning
Male genital system
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Snippet The human seminal vesicles secrete two proteins, semenogelin I and semenogelin II, at very high concentrations. It has previously been shown that the...
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SubjectTerms Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Mammalian male genital system
Morphology. Physiology
Vertebrates: reproduction
Title Semenogelin II Gene Is Replaced by a Truncated LINE1 Repeat in the Cotton-Top Tamarin
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