Striatal Dopamine D2/D3 Receptor Availability Is Reduced in Methamphetamine Dependence and Is Linked to Impulsivity - Lee, Buyean; London, EdyD; Poldrack, Russell A; Farahi, Judah; Nacca, Angelo; Monterosso, John R; Mumford, Jeanette A; Bokarius, Andrew V; Dahlbom, Magnus; Mukherjee, Jogeshwar; Bilder, Robert M; Brody, Arthur L; et al. (The Journal of neuroscience, 2009)
Keywords: Adult; Amphetamine-Related Disorders - diagnostic imaging; Amphetamine-Related Disorders - metabolism; Amphetamine-Related Disorders - physiopathology; Basal Ganglia - diagnostic imaging; Basal Ganglia - drug effects; Basal Ganglia - metabolism; Biomarkers - analysis; Biomarkers - metabolism; Caudate Nucleus - diagnostic imaging; Caudate Nucleus - drug effects; Caudate Nucleus - metabolism; Corpus Striatum - diagnostic imaging; Corpus Striatum - drug effects; Corpus Striatum - metabolism; Dopamine - metabolism; Dopamine Uptake Inhibitors - adverse effects; Down-Regulation - drug effects; Down-Regulation - physiology; Female; Functional Laterality - physiology; Humans; Image Processing, Computer-Assisted; Impulsive Behavior - chemically induced; Impulsive Behavior - metabolism; Impulsive Behavior - physiopathology; Male; Methamphetamine - adverse effects; Neuropsychological Tests; Nucleus Accumbens - diagnostic imaging; Nucleus Accumbens - drug effects; Nucleus Accumbens - metabolism; Positron-Emission Tomography; Putamen - diagnostic imaging; Putamen - drug effects; Putamen - metabolism; Receptors, Dopamine D2 - deficiency; Receptors, Dopamine D2 - drug effects; Receptors, Dopamine D3 - deficiency; Receptors, Dopamine D3 - drug effects; Young Adult