Enhanced pyruvate dehydrogenase activity does not affect muscle O2 uptake at onset of intense exercise in humans

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology Vol. 282; no. 1; p. 273
• Main Authors: Bangsbo, Jens, Gibala, Martin J, Krustrup, Peter, Gonzalez-Alonso, Jose, Saltin, Bengt
• Format: Journal Article
• Language: English
• Published: United States 01.01.2002
• Subjects: Adult; Dichloroacetic Acid - administration & dosage; Enzyme Activation - drug effects; Humans; Lactic Acid - biosynthesis; Lactic Acid - metabolism; Male; Muscle, Skeletal - blood supply; Muscle, Skeletal - enzymology; Oxygen - pharmacokinetics; Oxygen Consumption - physiology; Phosphocreatine - metabolism; Physical Exertion - physiology; Pyruvate Dehydrogenase Complex - metabolism; Pyruvic Acid - metabolism; Regional Blood Flow - physiology; Thigh

Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark It has been proposed that the activation state of pyruvate dehydrogenase (PDH) may influence the rate of skeletal muscle O 2 uptake during the initial phase of exercise; however...