Splenic peliosis with spontaneous splenic rupture in a patient with immune thrombocytopenia treated with danazol
We present a 79-year-old man diagnosed with immune thrombocytopenia (ITP), treated with danazol, who died as a result of a spontaneously ruptured spleen. The histopathological diagnosis was splenic peliosis. This patient presents a chronological association between the treatment with danazol and the...
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Published in | Haematologica (Roma) Vol. 83; no. 7; p. 666 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Italy
01.07.1998
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Subjects | |
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Abstract | We present a 79-year-old man diagnosed with immune thrombocytopenia (ITP), treated with danazol, who died as a result of a spontaneously ruptured spleen. The histopathological diagnosis was splenic peliosis. This patient presents a chronological association between the treatment with danazol and the development of peliosis, which suggests a clear cause-effect relationship. Facing an individual patient with ITP, clinicians should weigh the potential benefits of danazol with the possible development of serious complications, such as hepatic failure or splenic rupture due to peliosis. |
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AbstractList | We present a 79-year-old man diagnosed with immune thrombocytopenia (ITP), treated with danazol, who died as a result of a spontaneously ruptured spleen. The histopathological diagnosis was splenic peliosis. This patient presents a chronological association between the treatment with danazol and the development of peliosis, which suggests a clear cause-effect relationship. Facing an individual patient with ITP, clinicians should weigh the potential benefits of danazol with the possible development of serious complications, such as hepatic failure or splenic rupture due to peliosis. |
Author | Villanueva, C Monteagudo, D Sanchez, J Somolinos, N Javier Penalver, F Gallego, R |
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Snippet | We present a 79-year-old man diagnosed with immune thrombocytopenia (ITP), treated with danazol, who died as a result of a spontaneously ruptured spleen. The... |
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SubjectTerms | Aged Danazol - therapeutic use Hemoperitoneum - chemically induced Humans Male Splenic Diseases - chemically induced Splenic Rupture - chemically induced Testosterone Congeners - therapeutic use Thrombocytopenia - drug therapy Thrombocytopenia - immunology |
Title | Splenic peliosis with spontaneous splenic rupture in a patient with immune thrombocytopenia treated with danazol |
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