Analysis of Correlation Between Mitotic Index, MIB1 Score and S-phase Fraction as Proliferation Markers in Invasive Breast Carcinoma. Methodological Aspects and Prognostic Value in a Series of 257 Cases

• Published in: Anticancer research Vol. 24; no. 5B; pp. 3283 - 3288
• Main Authors: CALY, M, GENIN, P, ZIDANE, M, SASTRE-GARAU, X, AL GHUZLAN, A, ELIE, C, FRENEAUX, P, KLIJANIENKO, J, ROSTY, C, SIGAL-ZAFRANI, B, VINCENT-SALOMONI, A, DOUGGAZ, A
• Format: Journal Article
• Language: English
• Published: Attiki International Institute of Anticancer Research 01.09.2004
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Breast Neoplasms - pathology; Cell Division - physiology; Disease-Free Survival; Gynecology. Andrology. Obstetrics; Humans; Ki-67 Antigen - analysis; Mammary gland diseases; Medical sciences; Middle Aged; Mitotic Index; Neoplasm Staging; Prognosis; S Phase; Tumors; S-phase fraction; Prognosis; Biological marker; Breast cancer; Malignant tumor; MIB1; Mammary gland diseases; Breast carcinoma; Mitotic index; Score; Cancerology; Correlation analysis; S Phase; Cell cycle

Background: The study was designed in order to evaluate the degree of correlation of mitotic index (MI), Ki67 (MIB1) score and S-phase fraction (SPF) as markers of cell proliferation and prognosis in breast cancer. Materials and Methods: The series analysed corresponded to 257 consecutive invasive b...