Subset of Esophageal Adenocarcinoma Expresses Adhesion Molecule L1 in Contrast to Squamous Cell Carcinoma

• Published in: Anticancer research Vol. 29; no. 4; pp. 1195 - 1199
• Main Authors: RAWNAQ, Tamina, KLEINHANS, Helge, KAIFI, Jussuf T, UTO, Marius, SCHURR, Paulus G, REICHELT, Uta, CATALDEGIRMEN, Guellue, GAWAD, Karim A, YEKEBAS, Emre F, SCHACHNER, Melitta, IZBICKI, Jakob R
• Format: Journal Article
• Language: English
• Published: Attiki International Institute of Anticancer Research 01.04.2009
• Subjects: Adenocarcinoma - metabolism; Adenocarcinoma - secondary; Biological and medical sciences; Biomarkers, Tumor - metabolism; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - secondary; Esophageal Neoplasms - metabolism; Esophageal Neoplasms - pathology; Esophagus; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Immunoenzyme Techniques; Male; Medical sciences; Middle Aged; Neural Cell Adhesion Molecule L1 - metabolism; Prognosis; Retrospective Studies; Survival Rate; Tissue Array Analysis; Tumors; Skin disease; Squamous cell carcinoma; Basal cell carcinoma; tumor marker; Targeted therapy; Esophageal disease; Cell adhesion molecule; therapy target; Tumoral marker; Malignant tumor; Esophagus cancer; L1 cell adhesion molecule; Cancerology; Treatment; esophageal adenocarcinoma; Digestive diseases; Esophagus adenocarcinoma; Cell adhesion molecule L1; Cancer

Background: Esophageal adenocarcinoma is currently the most rapidly increasing cancer in Western populations. L1 (CD171), a neural cell adhesion molecule, has an essential function in tumor progression and has been shown to be expressed in the proliferating cells of the intestinal crypts in mice. Th...