Histologic, morphometric, and biochemical evolution of vein bypass grafts in a nonhuman primate model. III. Long-term changes and their modification by platelet inhibition with aspirin and dipyridamole

• Published in: The Journal of thoracic and cardiovascular surgery Vol. 99; no. 3; pp. 426 - 432
• Main Authors: Boerboom, LE, Olinger, GN, Liu, TZ, Rodriguez, ER, Ferrans, VJ, Kissebah, AH
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA AATS/WTSA 01.03.1990; Elsevier
• Subjects: Animals; Aspirin - pharmacology; Biological and medical sciences; Blood. Blood coagulation. Reticuloendothelial system; Cholesterol - analysis; Dipyridamole - pharmacology; Drug Administration Schedule; Endothelium, Vascular - pathology; Femoral Artery - surgery; Fibrosis; Foam Cells - pathology; Forearm - blood supply; Macaca; Medical sciences; Pharmacology. Drug treatments; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors; Time Factors; Veins - analysis; Veins - drug effects; Veins - pathology; Veins - transplantation; Monkey; Cardiovascular disease; Lipids; Histology; Long term; Cholesterol; Antiplatelet agent; Vertebrata; Chemotherapy; Mammalia; Treatment; Animal; Blood vessel; Primates; Graft; Arteriovenous bypass

The objectives of this study were to elucidate the long-term influence on vein bypass grafts of platelet inhibition and its late discontinuation. Cephalic vein grafts were interposed bilaterally in the femoral arteries of stump-tailed macaque monkeys fed a diet that sustains plasma cholesterol level...