Identification and kinetic characterization of acetylator genotype-dependent and -independent arylamine carcinogen N-acetyltransferases in hamster bladder cytosol

• Published in: Drug metabolism and disposition Vol. 17; no. 3; p. 231
• Main Authors: Yerokun, T, Kirlin, W G, Trinidad, A, Ferguson, R J, Ogolla, F, Andrews, A F, Brady, P K, Hein, D W
• Format: Journal Article
• Language: English
• Published: United States 01.05.1989
• Subjects: 4-Aminobenzoic Acid - metabolism; Acetylation; Acetyltransferases - metabolism; Aminosalicylic Acids - metabolism; Animals; Arylamine N-Acetyltransferase - isolation & purification; Arylamine N-Acetyltransferase - metabolism; Carcinogens - metabolism; Catalysis; Cricetinae; Cytosol - enzymology; Genotype; In Vitro Techniques; Kinetics; Mesocricetus; Proteins - metabolism; Urinary Bladder - enzymology

Recent studies from our laboratory have shown relatively high levels of polymorphic N-acetyltransferase (NAT)(EC 2.3.1.5) activity toward carcinogenic arylamines in urinary bladder cytosol of humans and in the inbred hamster model of the N-acetylation polymorphism. The expression of this polymorphis...