Insular Carcinoma: A Distinct Thyroid Carcinoma with Associated Iodine-131 Localization

Insular carcinoma, once considered a poorly-differentiated thyroid cancer, has been reclassified as a distinct thyroid neoplasm. Since this neoplasm is composed of follicular epithelial cells, it may concentrate radioiodide (131I) making postoperative 131I imaging for detection of metastases and rad...

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Bibliographic Details
Published inThe Journal of nuclear medicine (1978) Vol. 32; no. 7; pp. 1358 - 1363
Main Authors Justin, Eric P, Seabold, James E, Robinson, Robert A, Walker, William P, Gurll, Nelson J, Hawes, Donald R
Format Journal Article
LanguageEnglish
Published United States Soc Nuclear Med 01.07.1991
Subjects
Adult
Aged
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
Carcinoma - classification
Carcinoma - epidemiology
Carcinoma - pathology
CARCINOMAS
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ENDOCRINE GLANDS
Female
GLANDS
Humans
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
Iodine Radioisotopes - therapeutic use
ISOTOPES
Male
NEOPLASMS
NMR IMAGING
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIOISOTOPES 550601 > Medicine > Unsealed Radionuclides in Diagnostics
RADIOLOGY AND NUCLEAR MEDICINE
Retrospective Studies
THYROID
Thyroid Neoplasms - classification
Thyroid Neoplasms - epidemiology
Thyroid Neoplasms - pathology
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Summary:Insular carcinoma, once considered a poorly-differentiated thyroid cancer, has been reclassified as a distinct thyroid neoplasm. Since this neoplasm is composed of follicular epithelial cells, it may concentrate radioiodide (131I) making postoperative 131I imaging for detection of metastases and radiotherapy possible. A 20-yr review of 35 cases diagnosed as anaplastic or undifferentiated thyroid carcinoma at this medical center revealed five patients with insular carcinoma. Four patients showed postoperative 131I localization and received therapeutic doses of 131I. Three of the four showed extrathyroidal 131I localization in neoplastic lesions. In one patient, the resolution of metastatic lesions by magnetic resonance and 131I imaging suggests that 131I may have an important therapeutic role in this aggressive neoplasm.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0161-5505
1535-5667