Lung Thallium-201 Uptake During Exercise Emission Computed Tomography

• Published in: The Journal of nuclear medicine (1978) Vol. 32; no. 3; p. 417
• Main Authors: Kurata, Chinori, Tawarahara, Kei, Taguchi, Takahisa, Sakata, Kazuyuki, Yamazaki, Noboru, Naitoh, Yasutsugu
• Format: Journal Article
• Language: English
• Published: United States Soc Nuclear Med 01.03.1991
• Subjects: 550601 - Medicine- Unsealed Radionuclides in Diagnostics; 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man; Aged; BETA DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COMPUTERIZED TOMOGRAPHY; Coronary Disease - diagnostic imaging; DAYS LIVING RADIOISOTOPES; DIAGNOSIS; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; EXERCISE; Exercise Test; HEART; HEAVY NUCLEI; Humans; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; Lung - metabolism; LUNGS; Male; Middle Aged; Myocardium - metabolism; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT; RADIOISOTOPES; RADIOLOGY AND NUCLEAR MEDICINE; RADIONUCLIDE KINETICS; RESPIRATORY SYSTEM; SECONDS LIVING RADIOISOTOPES; THALLIUM 201; THALLIUM ISOTOPES; Thallium Radioisotopes - pharmacokinetics; TOMOGRAPHY; Tomography, Emission-Computed; UPTAKE
• ISSN: 0161-5505; 1535-5667

To test whether the analysis of lung uptake is worth adding to the interpretation of exercise thallium-201 (201TI) emission computed tomography (ECT), a lung/heart ratio of 201TI uptake was measured from an anterior image during ECT in 25 clinically normal (Group 1), 91 angiographically normal (Group 2), and 265 subjects with coronary artery disease (Group 3). The mean +2 s.d. of ratios in Groups 1 and 2 were the same (0.37). In Group 3, 80 subjects (30%) with increased ratios (greater than 0.37) had higher frequencies of prior infarction and multi-vessel disease, more severe left ventricular dysfunction, and 201TI defects than 185 subjects with normal ratios. Subjects with markedly increased ratios (greater than 0.45) had three-vessel disease more frequently than those with slightly or moderately increased ratios (67% versus 14% or 35%). Thus the measurement of lung/heart ratios may provide information regarding the severity of coronary artery disease and should be added to the routine interpretation of exercise ECT.