Differentiation of adult human mesenchymal stem cells: chondrogenic effect of BMP-2

• Published in: Pathologie biologie (Paris) Vol. 56; no. 5; pp. 326 - 333
• Main Authors: Freyria, A-M, Courtes, S, Mallein-Gerin, F
• Format: Journal Article
• Language: French
• Published: France Elsevier Masson 01.07.2008
• Subjects: Adult; Adult Stem Cells - cytology; Adult Stem Cells - drug effects; Animals; Biochemistry, Molecular Biology; Bone Morphogenetic Protein 2 - pharmacology; Bone Morphogenetic Protein 2 - physiology; Cell Differentiation; Cells, Cultured - cytology; Cells, Cultured - drug effects; Chondrocytes - cytology; Humans; Life Sciences; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - drug effects; Mice; Osteocytes - cytology; Phenotype; Tissue Engineering

Articular cartilage is essential for the motion of the skeleton. However, this tissue is unable to spontaneously repair once injured, since it is avascular and aneural. Numerous repair strategies are developed, but they do not lead to a functional tissue and research into cartilage repair focuses no...