Behavioral Characterization of Mice Lacking Histamine H3 Receptors
Brain histamine H 3 receptors are predominantly presynaptic and serve an important autoregulatory function for the release of histamine and other neurotransmitters. They have been implicated in a variety of brain functions, including arousal, locomotor activity, thermoregulation, food intake, and me...
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Published in | Molecular pharmacology Vol. 62; no. 2; p. 389 |
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Main Authors | , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English Japanese |
Published |
American Society for Pharmacology and Experimental Therapeutics
01.08.2002
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Abstract | Brain histamine H 3 receptors are predominantly presynaptic and serve an important autoregulatory function for the release of histamine and other
neurotransmitters. They have been implicated in a variety of brain functions, including arousal, locomotor activity, thermoregulation,
food intake, and memory. The recent cloning of the H 3 receptor in our laboratory has made it possible to create a transgenic line of mice devoid of H 3 receptors. This paper provides the first description of the H 3 receptor-deficient mouse (H 3 â/â ), including molecular and pharmacologic verification of the receptor deletion as well as phenotypic screens. The H 3 â/â mice showed a decrease in overall locomotion, wheel-running behavior, and body temperature during the dark phase but maintained
normal circadian rhythmicity. H 3 â/â mice were insensitive to the wake-promoting effects of the H 3 receptor antagonist thioperamide. We also observed a slightly decreased stereotypic response to the dopamine releaser, methamphetamine,
and an insensitivity to the amnesic effects of the cholinergic receptor antagonist, scopolamine. These data indicate that
the H 3 receptor-deficient mouse represents a valuable model for studying histaminergic regulation of a variety of behaviors and neurotransmitter
systems, including dopamine and acetylcholine. |
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AbstractList | Brain histamine H 3 receptors are predominantly presynaptic and serve an important autoregulatory function for the release of histamine and other
neurotransmitters. They have been implicated in a variety of brain functions, including arousal, locomotor activity, thermoregulation,
food intake, and memory. The recent cloning of the H 3 receptor in our laboratory has made it possible to create a transgenic line of mice devoid of H 3 receptors. This paper provides the first description of the H 3 receptor-deficient mouse (H 3 â/â ), including molecular and pharmacologic verification of the receptor deletion as well as phenotypic screens. The H 3 â/â mice showed a decrease in overall locomotion, wheel-running behavior, and body temperature during the dark phase but maintained
normal circadian rhythmicity. H 3 â/â mice were insensitive to the wake-promoting effects of the H 3 receptor antagonist thioperamide. We also observed a slightly decreased stereotypic response to the dopamine releaser, methamphetamine,
and an insensitivity to the amnesic effects of the cholinergic receptor antagonist, scopolamine. These data indicate that
the H 3 receptor-deficient mouse represents a valuable model for studying histaminergic regulation of a variety of behaviors and neurotransmitter
systems, including dopamine and acetylcholine. |
Author | Ann J. Barbier Ying Wu Timothy W. Lovenberg Jingcai Chen Karen Ngo Muriel Koehl Takehiko Watanabe China Weber Kazuhiko Yanai Eiko Sakurai Christine Dugovic Hiroshi Toyota Doo Hyun Lee Aaron D. Laposky Changlu Liu Wai-Ping Fung-Leung Fred W. Turek |
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Snippet | Brain histamine H 3 receptors are predominantly presynaptic and serve an important autoregulatory function for the release of histamine and other... |
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Title | Behavioral Characterization of Mice Lacking Histamine H3 Receptors |
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