Chemistry and Biological Behavior of Samarium-153 and Rhenium-186-Labeled Hydroxyapatite Particles : Potential Radiopharmaceuticals for Radiation Synovectomy

• Published in: The Journal of nuclear medicine (1978) Vol. 34; no. 9; pp. 1536 - 1542
• Main Authors: Chinol, Marco, Vallabhajosula, Shankar, Goldsmith, Stanley J, Klein, Michael J, Deutsch, Karen F, Chinen, Lori K, Brodack, James W, Deutsch, Edward A, Watson, Barbara A, Tofe, Andrew J
• Format: Journal Article
• Language: English
• Published: United States Soc Nuclear Med 01.09.1993
• Subjects: Animals; Arthritis, Experimental - radiotherapy; Durapatite; Hydroxyapatites - chemistry; Hydroxyapatites - therapeutic use; Injections, Intra-Articular; Rabbits; Radioisotopes - chemistry; Radioisotopes - therapeutic use; Rhenium - chemistry; Rhenium - therapeutic use; Samarium - chemistry; Samarium - therapeutic use; Synovial Membrane - radiation effects

Hydroxyapatite (HA), a natural constituent of bone, was studied as a particulate carrier for beta-emitting radionuclides in radiation synovectomy. Particles were radiolabeled with 153Sm or 186Re and their in vivo safety was investigated following intra-articular injection into knees of normal rabbit...