M1 Receptor-Mediated Nitric Oxide-Dependent Relaxation Unmasked in Stomach Fundus from M3 Receptor Knockout Mice

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 304; no. 2; pp. 675 - 682
• Main Authors: Stengel, Peter W, Cohen, Marlene L
• Format: Journal Article
• Language: English
• Published: United States American Society for Pharmacology and Experimental Therapeutics 01.02.2003
• Subjects: Animals; Cyclooxygenase Inhibitors - pharmacology; Dose-Response Relationship, Drug; Electric Stimulation - methods; Gastric Fundus - drug effects; Gastric Fundus - physiology; In Vitro Techniques; Male; Mice; Mice, Knockout; Muscarinic Agonists - pharmacology; Muscle Relaxation - drug effects; Muscle Relaxation - physiology; Nitric Oxide - antagonists & inhibitors; Nitric Oxide - physiology; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Receptors, Muscarinic - deficiency; Receptors, Muscarinic - genetics; Receptors, Muscarinic - physiology

Muscarinic receptors can mediate both contractile and relaxant responses in smooth muscle. The stomach fundus from wild-type mice possesses a neuronal M 1 receptor that mediates relaxation to carbamylcholine and (4-hydroxy-2-butynyl)-1-trimethylammonium-3-chlorocarbanilate chloride (McN-A-343) but i...