Dose- and time-dependent changes in phencyclidine metabolite covalent binding in rats and the possible role of CYP2D1

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 265; no. 3; pp. 1261 - 1266
• Main Authors: Owens, S M, Gunnell, M, Laurenzana, E M, Valentine, J L
• Format: Journal Article
• Language: English
• Published: United States American Society for Pharmacology and Experimental Therapeutics 01.06.1993
• Subjects: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System - metabolism; Dose-Response Relationship, Drug; Drug Administration Schedule; Isoenzymes - antagonists & inhibitors; Isoenzymes - metabolism; Male; Microsomes, Liver - drug effects; Microsomes, Liver - enzymology; Phencyclidine - administration & dosage; Phencyclidine - blood; Phencyclidine - metabolism; Rats; Rats, Sprague-Dawley

We determined whether chronic dosing with phencyclidine (PCP) could affect the in vitro function of liver microsomal enzymes in male Sprague-Dawley rats. PCP chronic dosing of rats (n = 3 per group) for 3 days with 2.5, 10 and 18 mg/kg/day caused a dose-dependent decrease (23, 36 and 53%, respective...