Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumourchemoresistance

• Published in: EMBO molecular medicine
• Main Authors: Duluc, Camille, Moatassim-Billah, Siham, Chalabi-Dchar, Mounira, Perraud, Aurélie, Samain, Rémi, Breibach, Florence, Gayral, Marion, Cordelier, Pierre, Delisle, Marie-Bernadette, Bousquet-Dubouch, Marie-Pierre, Tomasini, Richard, Schmid, Herbert, Mathonnet, Muriel, Pyronnet, Stéphane, Martineau, Yvan, Bousquet, Corinne
• Format: Journal Article
• Language: English
• Published: Wiley Open Access 01.06.2015
• Subjects: Cancer; Life Sciences; STARRING ROLE; TUMOR PROGRESSION; DUCTAL ADENOCARCINOMA; STELLATE CELLS; MOUSE MODELS; cancer-associated fibroblasts; chemoresistance; pancreatic cancer; THERAPY; MICROENVIRONMENT; pharmacotherapy; PI3K PATHWAY; protein synthesis and secretion; SST2 SOMATOSTATIN RECEPTOR; STROMA

Pancreatic ductal adenocarcinoma (PDAC) is extremely stroma-rich. Cancer-associated fibroblasts (CAFs) secrete proteins that activate survival and promote chemoresistance of cancer cells. Our results demonstrate that CAF secretome-triggered chemoresistance is abolished upon inhibition of the protein...