Pharmacology of a mixed 5-hydroxytryptamine1A/dopamine agonist

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 268; no. 3; pp. 1304 - 1310
• Main Authors: PIERCEY, M. F, TANG, A. H, SMITH, M. W, SZMUSZKOVICZ, J, LAHTI, R. A, VONVOIGTLANDER, P. F, SCHREUR, P. J. K. D, MCCALL, R. B, LUM-RAGAN, J. T, HOFFMANN, W. E, FRANKLIN, S. R, CODE, R. A
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Pharmacology and Experimental Therapeutics 01.03.1994
• Subjects: Animals; Behavior, Animal - drug effects; Biological and medical sciences; Diazepam - pharmacology; Dopamine Agents - pharmacology; Male; Medical sciences; Mice; Molecular Structure; Neurons - drug effects; Neurons - metabolism; Neuropharmacology; Pharmacology. Drug treatments; Phenalenes; Polycyclic Compounds - pharmacology; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2 - drug effects; Serotonin Receptor Agonists - pharmacology; Rat; Psychotropic; Rodentia; Discharge pattern; Electrophysiology; Serotonin agonist; In vitro; Biological activity; In vivo; Vertebrata; Mammalia; D2 Dopamine receptor; Tranquillizer; Mouse; Animal; Dopamine agonist; S1A receptor; Behavior

U-67413B (4-hydroxydipropylaminodihydrophenalene) bound with high affinity to both 5-hydroxytryptamine (HT)1A and D2-dopamine (DA) receptor sites. U-67413B depressed 5-HT and DA cell firing rates and depressed synthesis of both neurotransmitters. The drug depressed mouse body temperatures by an amou...