Infection of the maternal-fetal interface and vertical transmission following low-dose inoculation of pregnant rhesus macaques

• Published in: PloS one Vol. 18; no. 5; p. e0284964
• Main Authors: Koenig, Michelle R, Mitzey, Ann M, Morgan, Terry K, Zeng, Xiankun, Simmons, Heather A, Mejia, Andres, Leyva Jaimes, Fernanda, Keding, Logan T, Crooks, Chelsea M, Weiler, Andrea M, Bohm, Ellie K, Aliota, Matthew T, Friedrich, Thomas C, Mohr, Emma L, Golos, Thaddeus G
• Format: Journal Article
• Language: English
• Published: Public Library of Science 04.05.2023
• Subjects: Africa; Analysis; Asia; Birth defects; Brazil; Dams; Disease transmission; Health aspects; Infection; Pregnant women; Virus diseases; Africa; Brazil; Asia

Congenital Zika virus (ZIKV) infection can result in birth defects, including malformations in the fetal brain and visual system. There are two distinct genetic lineages of ZIKV: African and Asian. Asian-lineage ZIKVs have been associated with adverse pregnancy outcomes in humans; however, recent ev...