Disruption of Interleukin-1[beta] Autocrine Signaling Rescues Complex I Activity and Improves ROS Levels in Immortalized Epithelial Cells with Impaired Cystic Fibrosis Transmembrane Conductance Regulator

• Published in: PloS one Vol. 9; no. 6
• Main Authors: Clauzure, Mariángeles, Valdivieso, Angel G, Massip Copiz, María M, Schulman, Gustavo, Teiber, María Luz, Santa-Coloma, Tomás A
• Format: Journal Article
• Language: English
• Published: Public Library of Science 05.06.2014
• Subjects: Cystic fibrosis; Interleukins; Proteins; RNA

Patients with cystic fibrosis (CF) have elevated concentration of cytokines in sputum and a general inflammatory condition. In addition, CF cells in culture produce diverse cytokines in excess, including IL-1[beta]. We have previously shown that IL-1[beta], at low doses (~30 pM), can stimulate the e...