Suppressor of Cytokine Signaling

• Published in: PloS one Vol. 8; no. 8; p. e70536
• Main Authors: Linossi, Edmond M, Chandrashekaran, Indu R, Kolesnik, Tatiana B, Murphy, James M, Webb, Andrew I, Willson, Tracy A, Kedzierski, Lukasz, Bullock, Alex N, Babon, Jeffrey J, Norton, Raymond S, Nicola, Nicos A, Nicholson, Sandra E
• Format: Journal Article
• Language: English
• Published: Public Library of Science 21.08.2013
• Subjects: Cytokines; Epidermal growth factors

Suppressor of Cytokine Signaling (SOCS)5 is thought to act as a tumour suppressor through negative regulation of JAK/STAT and epidermal growth factor (EGF) signaling. However, the mechanism/s by which SOCS5 acts on these two distinct pathways is unclear. We show for the first time that SOCS5 can int...