Manganese Superoxide Dismutase

• Published in: PloS one Vol. 9; no. 5
• Main Authors: Mohammedi, Kamel, Bellili-Muñoz, Naïma, Driss, Fathi, Roussel, Ronan, Seta, Nathalie, Fumeron, Frédéric, Hadjadj, Samy, Marre, Michel, Velho, Gilberto
• Format: Journal Article
• Language: English
• Published: Public Library of Science 12.05.2014
• Subjects: Diabetic nephropathies; Diabetic retinopathy; Genetic aspects; Mitochondrial DNA; Oxidation-reduction reactions; Physiological aspects; Single nucleotide polymorphisms; Superoxides; Type 1 diabetes

Oxidative stress is involved in the pathophysiology of diabetic nephropathy. Manganese superoxide dismutase (SOD2) catalyses the dismutation of superoxide, regulates the metabolism of reactive oxygen species in the mitochondria and is highly expressed in the kidney. Plasma concentration of advanced...