Long non-coding RNA PVT1 regulates TGF-[beta] and promotes the proliferation, migration and invasion of hypopharyngeal carcinoma FaDu cells

• Published in: World journal of surgical oncology Vol. 22; no. 1
• Main Authors: Zhao, Yan, Zhao, Lei, Li, Maocai, Meng, Zhen, Wang, Song, Li, Jun, Li, Lianqing, Gong, Lili
• Format: Journal Article
• Language: English
• Published: BioMed Central Ltd 20.09.2024
• Subjects: Animal experimentation; Bone morphogenetic proteins; Cancer; Carcinoma; Cells; Development and progression; Health aspects; Lymphomas; Metastasis; Prognosis; RNA; Transforming growth factors; China
• DOI: 10.1186/s12957-024-03536-w
• ISSN: 1477-7819

Hypopharyngeal carcinoma is one of the malignant tumors of the head and neck with a particularly poor prognosis. Recurrence and metastasis are important reasons for poor prognosis of hypopharyngeal cancer patients, and malignant proliferation, migration, and invasion of tumor cells are important factors for recurrence and metastasis of hypopharyngeal cancer. Therefore, elucidating hypopharyngeal cancer cells' proliferation, migration, and invasion mechanism is essential for improving diagnosis, treatment, and prognosis. Plasmacytoma Variant Translocation 1 (PVT1) is considered a potential diagnostic marker and therapeutic target for tumors. However, it remains unclear whether PVT1 is related to the occurrence and development of hypopharyngeal cancer and its specific mechanism. In this study, the promoting effect of PVT1 on the proliferation, migration, and invasion of hypopharyngeal carcinoma FaDu cells was verified by cell biology experiments and animal studies, and it was found that PVT1 inhibited the expression of TGF-[beta], suggesting that PVT1 may regulate the occurrence and development of hypopharyngeal carcinoma FaDu cells through TGF-[beta]. Keywords: Hypopharyngeal carcinoma, FaDu cells, Long noncoding RNA PVT1, Transforming growth factor-[beta]