Inhibition of ROS-mediated activation Src-MAPK/AKT signaling by orientin alleviates [H.sub.2][O.sub.2]-induced apoptosis in PC12 cells

• Published in: Drug design, development and therapy Vol. 10; p. 3973
• Main Authors: Qi, Shimei, Feng, Zunyong, Li, Qiang, Qi, Zhilin, Zhang, Yao
• Format: Journal Article
• Language: English
• Published: Dove Medical Press Limited 01.01.2018
• Subjects: Apoptosis; Hydrogen peroxide; Monosaccharides; Nervous system diseases; Neurodegenerative diseases; Neurons; Oxidative stress; Peroxides; Pheochromocytoma; Proteins; Toxicity

Purpose: Reactive oxygen species (ROS) are considered a direct cause of neurodegenerative diseases (NDDs). Drugs developed to target ROS are effective for the treatment of NDDs. Orientin is a pyrone glucoside extracted from Polygonum orientale, and it exhibits many pharmacological activities. In thi...