Silver staining (Campbell-Switzer) of neuronal [alpha]-synuclein assemblies induced by multiple system atrophy and Parkinson's disease brain extracts in transgenic mice

• Published in: Acta neuropathologica communications Vol. 7; no. 1
• Main Authors: Lavenir, Isabelle, Passarella, Daniela, Masuda-Suzukake, Masami, Curry, Annabelle, Holton, Janice L, Ghetti, Bernardino, Goedert, Michel
• Format: Journal Article
• Language: English
• Published: BioMed Central Ltd 16.09.2019
• Subjects: Comparative analysis; Dementia; Gene expression; Genetic engineering; Multiple system atrophy; Neurons

Synucleinopathies [Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA)] share filamentous [alpha]-synuclein assemblies in nerve cells and glial cells. We compared the abilities of brain extracts from MSA and PD patients to induce neuronal [alpha]-synuclei...