Assembly of [alpha]-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of [alpha]-synuclein seeds

• Published in: Acta neuropathologica communications Vol. 9; no. 1
• Main Authors: Macdonald, Jennifer A, Chen, John L, Masuda-Suzukake, Masami, Schweighauser, Manuel, Jaunmuktane, Zane, Warner, Thomas, Holton, Janice L, Grossman, Annabelle, Berks, Richard, Lavenir, Isabelle, Goedert, Michel
• Format: Journal Article
• Language: English
• Published: BioMed Central Ltd 24.11.2021
• Subjects: Genetic engineering; Neurons; Seeds

Peripheral administration (oral, intranasal, intraperitoneal, intravenous) of assembled A53T [alpha]-synuclein induced synucleinopathy in heterozygous mice transgenic for human mutant A53T [alpha]-synuclein (line M83). The same was the case when cerebellar extracts from a case of multiple system atr...